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Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics
As ligand-regulated transcription factors, the nuclear hormone receptors are nearly ideal drug targets, with internal pockets that bind to hydrophobic, drug-like molecules and well-characterized ligand-induced conformational changes that recruit transcriptional coregulators to promoter elements. Yet...
שמור ב:
| Main Authors: | , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2010
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677810/ https://ncbi.nlm.nih.gov/pubmed/20148675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-physiol-021909-135917 |
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