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Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics
As ligand-regulated transcription factors, the nuclear hormone receptors are nearly ideal drug targets, with internal pockets that bind to hydrophobic, drug-like molecules and well-characterized ligand-induced conformational changes that recruit transcriptional coregulators to promoter elements. Yet...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677810/ https://ncbi.nlm.nih.gov/pubmed/20148675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-physiol-021909-135917 |
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