Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages

SNARE proteins drive membrane fusion by assembling into a four-helix bundle in a zippering process. Here we used optical tweezers to observe in real time a long-sought SNARE assembly intermediate in which only the membrane-distal N-terminal half of the bundle is assembled. Our finding supports the z...

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Bibliographic Details
Main Authors:	Gao, Ying, Zorman, Sylvain, Gundersen, Gregory, Xi, Zhiqun, Ma, Lu, Sirinakis, George, Rothman, James E., Zhang, Yongli
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3677750/ https://ncbi.nlm.nih.gov/pubmed/22903523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1224492
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Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages

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