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Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages
SNARE proteins drive membrane fusion by assembling into a four-helix bundle in a zippering process. Here we used optical tweezers to observe in real time a long-sought SNARE assembly intermediate in which only the membrane-distal N-terminal half of the bundle is assembled. Our finding supports the z...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677750/ https://ncbi.nlm.nih.gov/pubmed/22903523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1224492 |
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