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The Mechanism of E. coli RNA Polymerase Regulation by ppGpp Is Suggested by the Structure of Their Complex
Guanosine tetraphosphate (ppGpp) is an alarmone that enables bacterial adaptation to their environment. It has been known for years that ppGpp acts directly on RNA polymerase (RNAP) to alter the rate of transcription, but its exact target site is still under debate. Here we report a crystal structur...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677725/ https://ncbi.nlm.nih.gov/pubmed/23623685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.03.020 |
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