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5-Lipoxygenase-Activating Protein as a Modulator of Olanzapine-Induced Lipid Accumulation in Adipocyte

Experiments were performed in 3T3-L1 preadipocytes differentiated in vitro into adipocytes. Cells were treated with olanzapine and a 5-lipoxygenase (5-LOX) activating protein (FLAP) inhibitor MK-886. Lipid content was measured using an Oil Red O assay; 5-LOX and FLAP mRNA content was measured using...

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Autors principals: Dzitoyeva, Svetlana, Chen, Hu, Manev, Hari
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677661/
https://ncbi.nlm.nih.gov/pubmed/23762565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/864593
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