Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors

The HIV-1 protein Tat is a critical regulator of viral transcription and has also been implicated as a mediator of HIV-1 induced neurotoxicity. Here using a high throughput screening assay, we identified the GSK-3 inhibitor 6BIO, as a Tat-dependent HIV-1 transcriptional inhibitor. Its ability to inh...

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Detalhes bibliográficos
Main Authors: Kehn-Hall, Kylene, Guendel, Irene, Carpio, Lawrence, Skaltsounis, Leandros, Meijer, Laurent, Al-Harthi, Lena, Steiner, Joseph P., Nath, Avindra, Kutsch, Olaf, Kashanchi, Fatah
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677548/
https://ncbi.nlm.nih.gov/pubmed/21514616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2011.03.025
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