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TALEN-based Gene Correction for Epidermolysis Bullosa
Recessive dystrophic epidermolysis bullosa (RDEB) is characterized by a functional deficit of type VII collagen protein due to gene defects in the type VII collagen gene (COL7A1). Gene augmentation therapies are promising, but run the risk of insertional mutagenesis. To abrogate this risk, we explor...
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| Hlavní autoři: | , , , , , , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677309/ https://ncbi.nlm.nih.gov/pubmed/23546300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.56 |
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