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Conformational heterogeneity of the protein-free human spliceosomal U2-U6 snRNA complex
The complex formed between the U2 and U6 small nuclear (sn)RNA molecules of the eukaryotic spliceosome plays a critical role in the catalysis of precursor mRNA splicing. Here, we have used enzymatic structure probing, (19)F NMR, and analytical ultracentrifugation techniques to characterize the fold...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677266/ https://ncbi.nlm.nih.gov/pubmed/23426875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.038265.113 |
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