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Smoothened Regulates Activator and Repressor Functions of Hedgehog Signaling via Two Distinct Mechanisms()

The secreted protein Hedgehog (Hh) plays an important role in metazoan development and as a survival factor for many human tumors. In both cases, Hh signaling proceeds through the activation of the seven-transmembrane protein Smoothened (Smo), which is thought to convert the Gli family of transcript...

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Bibliografiska uppgifter
Huvudupphovsmän: Ogden, Stacey K., Casso, David J., Ascano, Manuel, Yore, Mark M., Kornberg, Thomas B., Robbins, David J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2006
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677211/
https://ncbi.nlm.nih.gov/pubmed/16423832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M510169200
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