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Mechanism of action of chromogranin A on catecholamine release: molecular modeling of the catestatin region reveals a β-strand/loop/β-strand structure secured by hydrophobic interactions and predictive of activity

A novel fragment of chromogranin A, known as ‘catestatin’ (bovine chromogranin A(344–364)), inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist, and may therefore constitute an endogenous autocrine feedback re...

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Autori principali: Tsigelny, Igor, Mahata, Sushil K., Taupenot, Laurent, Preece, Nicholas E., Mahata, Manjula, Khan, Imran, Parmer, Robert J., O’Connor, Daniel T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676947/
https://ncbi.nlm.nih.gov/pubmed/9809795
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