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Synthesis, Cytotoxicity, DNA Binding and Apoptosis of Rhein-Phosphonate Derivatives as Antitumor Agents

Several rhein-phosphonate derivatives (5a–c) were synthesized and evaluated for in vitro cytotoxicity against HepG-2, CNE, Spca-2, Hela and Hct-116 cell lines. Some compounds showed relatively high cytotoxicity. Especially compounds 5b exhibited the strongest cytotoxicity against HepG-2 and Spca-2 c...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ye, Man-Yi, Yao, Gui-Yang, Wei, Jing-Chen, Pan, Ying-Ming, Liao, Zhi-Xin, Wang, Heng-Shan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Molecular Diversity Preservation International (MDPI) 2013
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676791/
https://ncbi.nlm.nih.gov/pubmed/23629673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms14059424
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