Synthesis, Metabolism and In Vitro Cytotoxicity Studies on Novel Lavendamycin Antitumor Agents

A series of lavendamycin analogues with two, three or four substituents at the C-6, C-7 N, C-2′, C-3′ and C-11′ positions were synthesized via short and efficient methods and evaluated as potential NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor agents. The compounds were prepared through P...

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Detalhes bibliográficos
Main Authors: Cai, Wen, Hassani, Mary, Karki, Rajesh, Walter, Ervin D., Koelsch, Katherine H., Seradj, Hassan, Lineswala, Jayana P., Mirzaei, Hamid, York, Jeremy S., Olang, Fatemeh, Sedighi, Minoo, Lucas, Jennifer S., Eads, Thomas J., Rose, Anthony S., Charkhzarrin, Sahba, Hermann, Nicholas G., Beall, Howard D., Behforouz, Mohammad
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841014/
https://ncbi.nlm.nih.gov/pubmed/20149966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.01.037
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