Synthesis and Evaluation of Antitumor Activity of Novel N-Acyllavendamycin Analogues and Quinoline -5,8- diones

A series of 7-N-acyllavendamycins with zero, one or two substitutents at the C-2′, C-3′ and C-11′ were synthesized through short and efficient methods. Pictet-Spengler condensation of 7-N-acylamino-2-formylquinoline-5,8-diones with tryptamine or tryptophans produced the desired lavendamycins. Screen...

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Detalhes bibliográficos
Main Authors: Behforouz, Mohammad, Cai, Wen, Mohammadi, Farahnaz, Stocksdale, Mark G., Gu, Zhengxiang, Ahmadian, Mohammad, Baty, Darric E., Etling, Michele R., Al-Anzi, Charmaine H., Swiftney, Tyson M., Tanzer, Lee R., Merriman, Ronald R., Behforouz, Nancy C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900071/
https://ncbi.nlm.nih.gov/pubmed/17035024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.09.039
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