Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities

Fourteen novel amino-quinoline-5,8-dione derivatives (6a-h and 7a-h) were designed and synthesized by coupling different alkyl-or aryl-amino fragments at the C6-or C7-position of quinoline-5,8-dione. All target compounds showed antiproliferative potency in the low micromolar range in both drug sensi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Eur J Med Chem
Päätekijät: Ling, Yong, Yang, Qiu-Xing, Teng, Yu-Ning, Chen, Shi, Gao, Wei-Jie, Guo, Jing, Hsu, Pei-Ling, Liu, Yue, Morris-Natschke, Susan L., Hung, Chin-Chuan, Lee, Kuo-Hsiung
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421848/
https://ncbi.nlm.nih.gov/pubmed/29803003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.05.025
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