A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms

Polycythemia vera, essential thrombocythemia and primary myelofibrosis are myeloproliferative neoplasms (MPN) characterized by multilineage clonal hematopoiesis(1–5). Given that the identical somatic activating mutation in the JAK2 tyrosine kinase gene (JAK2(V617F)) is observed in most individuals w...

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Autori principali: Kilpivaara, Outi, Mukherjee, Semanti, Schram, Alison M, Wadleigh, Martha, Mullally, Ann, Ebert, Benjamin L, Bass, Adam, Marubayashi, Sachie, Heguy, Adriana, Garcia-Manero, Guillermo, Kantarjian, Hagop, Offit, Kenneth, Stone, Richard M, Gilliland, D Gary, Klein, Robert J, Levine, Ross L
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676425/
https://ncbi.nlm.nih.gov/pubmed/19287384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.342
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