Thyroid Hormone Reverses Aging-Induced Myocardial Fatty Acid Oxidation Defects and Improves the Response to Acutely Increased Afterload

BACKGROUND: Subclinical hypothyroidism occurs during aging in humans and mice and may contribute to the development of heart failure. Aging also impairs myocardial fatty acid oxidation, causing increased reliance on flux through pyruvate dehydrogenase (PDH) to maintain function. We hypothesize that...

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Hlavní autoři: Ledee, Dolena, Portman, Michael A., Kajimoto, Masaki, Isern, Nancy, Olson, Aaron K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676337/
https://ncbi.nlm.nih.gov/pubmed/23762386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065532
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