BAK and NOXA Are Critical Determinants of Mitochondrial Apoptosis Induced by Bortezomib in Mesothelioma

Based on promising preclinical efficacy associated with the 20S proteasome inhibitor bortezomib in malignant pleural mesothelioma (MPM), two phase II clinical trials have been initiated (EORTC 08052 and ICORG 05–10). However, the potential mechanisms underlying resistance to this targeted drug in MP...

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Detalhes bibliográficos
Main Authors: Busacca, Sara, Chacko, Alex D., Klabatsa, Astero, Arthur, Kenneth, Sheaff, Michael, Gunasekharan, Vignesh K., Gorski, Julia J., El-Tanani, Mohamed, Broaddus, V. Courtney, Gaudino, Giovanni, Fennell, Dean A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676324/
https://ncbi.nlm.nih.gov/pubmed/23762382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065489
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