Autophagy Correlates with the Therapeutic Responsiveness of Malignant Pleural Mesothelioma in 3D Models

Malignant pleural mesothelioma is a highly chemoresistant solid tumor. We have studied this apoptotic resistance using in vitro and ex vivo three-dimensional models, which acquire a high level of chemoresistance that can be reduced by PI3K/mTOR inhibitors. Here, we investigate the activity of GDC-09...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Barbone, Dario, Follo, Carlo, Echeverry, Nohemy, Gerbaudo, Victor H., Klabatsa, Astero, Bueno, Raphael, Felley-Bosco, Emanuela, Broaddus, V. Courtney
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540424/
https://ncbi.nlm.nih.gov/pubmed/26284517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134825
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