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Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin

We report the structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets an epitope on the HA stem similar to those...

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Bibliografski detalji
Glavni autori: Dreyfus, Cyrille, Ekiert, Damian C., Wilson, Ian A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676097/
https://ncbi.nlm.nih.gov/pubmed/23552413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02975-12
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