Mutational Inactivation of Herpes Simplex Virus 1 MicroRNAs Identifies Viral mRNA Targets and Reveals Phenotypic Effects in Culture

Herpes simplex virus 1 (HSV-1), a ubiquitous human pathogen, expresses several viral microRNAs (miRNAs). These, along with the latency-associated transcript, represent the only viral RNAs detectable in latently infected neuronal cells. Here, for the first time, we analyze which HSV-1 miRNAs are load...

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Detalhes bibliográficos
Main Authors: Flores, Omar, Nakayama, Sanae, Whisnant, Adam W., Javanbakht, Hassan, Cullen, Bryan R., Bloom, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676078/
https://ncbi.nlm.nih.gov/pubmed/23536669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00504-13
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