Toll-Like Receptor 5-Dependent Immunogenicity and Protective Efficacy of a Recombinant Fusion Protein Vaccine Containing the Nontoxic Domains of Clostridium difficile Toxins A and B and Salmonella enterica Serovar Typhimurium Flagellin in a Mouse Model of Clostridium difficile Disease

Clostridium difficile is a spore-forming bacillus that produces toxin-mediated enteric disease. C. difficile expresses two major virulence factors, toxin A (TcdA) and toxin B (TcdB). Human and animal studies demonstrate a clear association between humoral immunity to these toxins and protection agai...

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Bibliographic Details
Main Authors: Ghose, Chandrabali, Verhagen, Janneke M., Chen, Xinhua, Yu, Jian, Huang, Yaoxing, Chenesseau, Olivia, Kelly, Ciarán P., Ho, David D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676027/
https://ncbi.nlm.nih.gov/pubmed/23545305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01074-12
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