Perturbed Length–Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

RATIONALE: High-myofilament Ca(2+)-sensitivity has been proposed as trigger of disease pathogenesis in familial hypertrophic cardiomyopathy (HCM) based on in vitro and transgenic mice studies. However, myofilament Ca(2+)-sensitivity depends on protein phosphorylation and muscle length, and at presen...

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Autors principals: Sequeira, Vasco, Wijnker, Paul J.M., Nijenkamp, Louise L.A.M., Kuster, Diederik W.D., Najafi, Aref, Witjas-Paalberends, E. Rosalie, Regan, Jessica A., Boontje, Nicky, ten Cate, Folkert J., Germans, Tjeerd, Carrier, Lucie, Sadayappan, Sakthivel, van Slegtenhorst, Marjon A., Zaremba, Ruud, Foster, D. Brian, Murphy, Anne M., Poggesi, Corrado, dos Remedios, Cris, Stienen, Ger J.M., Ho, Carolyn Y., Michels, Michelle, van der Velden, Jolanda
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675884/
https://ncbi.nlm.nih.gov/pubmed/23508784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.300436
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