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Dose Selection Based on Physiologically Based Pharmacokinetic (PBPK) Approaches
Physiologically based pharmacokinetic (PBPK) models are built using differential equations to describe the physiology/anatomy of different biological systems. Readily available in vitro and in vivo preclinical data can be incorporated into these models to not only estimate pharmacokinetic (PK) param...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3675752/ https://ncbi.nlm.nih.gov/pubmed/23269526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9446-2 |
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