Pharmacokinetics of Levodopa, Carbidopa, and 3-O-Methyldopa Following 16-hour Jejunal Infusion of Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson’s Disease Patients

Motor complications of Parkinson’s disease (PD) are a consequence of pulsatile dopaminergic stimulation from standard oral levodopa therapy. Levodopa–carbidopa intestinal gel (LCIG) is infused continuously via an intrajejunal percutaneous gastrostomy tube. This was the first study designed to charac...

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Autores principales: Nyholm, Dag, Odin, Per, Johansson, Anders, Chatamra, Krai, Locke, Charles, Dutta, Sandeep, Othman, Ahmed A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675750/
https://ncbi.nlm.nih.gov/pubmed/23229334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9439-1
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