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Pharmacokinetics of Levodopa, Carbidopa, and 3-O-Methyldopa Following 16-hour Jejunal Infusion of Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson’s Disease Patients

Motor complications of Parkinson’s disease (PD) are a consequence of pulsatile dopaminergic stimulation from standard oral levodopa therapy. Levodopa–carbidopa intestinal gel (LCIG) is infused continuously via an intrajejunal percutaneous gastrostomy tube. This was the first study designed to charac...

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Detalhes bibliográficos
Main Authors: Nyholm, Dag, Odin, Per, Johansson, Anders, Chatamra, Krai, Locke, Charles, Dutta, Sandeep, Othman, Ahmed A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675750/
https://ncbi.nlm.nih.gov/pubmed/23229334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9439-1
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