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Predictions of In Vivo Prolactin Levels from In Vitro K(i) Values of D(2) Receptor Antagonists Using an Agonist–Antagonist Interaction Model
Prolactin elevation is a side effect of all currently available D(2) receptor antagonists used in the treatment of schizophrenia. Prolactin elevation is the result of a direct antagonistic D(2) effect blocking the tonic inhibition of prolactin release by dopamine. The aims of this work were to asses...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer US
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3675734/ https://ncbi.nlm.nih.gov/pubmed/23392818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9450-6 |
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