Dissecting the Roles of Tyrosines 490 and 785 of TrkA Protein in the Induction of Downstream Protein Phosphorylation Using Chimeric Receptors

Receptor tyrosine kinases generally act by forming phosphotyrosine-docking sites on their own endodomains that propagate signals through cascades of post-translational modifications driven by the binding of adaptor/effector proteins. The pathways that are stimulated in any given receptor tyrosine ki...

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Bibliographic Details
Main Authors: Biarc, Jordane, Chalkley, Robert J., Burlingame, A. L., Bradshaw, Ralph A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675596/
https://ncbi.nlm.nih.gov/pubmed/23589303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.475285
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