A Molecular Mechanism for Therapeutic Effects of cGMP-elevating Agents in Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a progressive, usually fatal disease with abnormal vascular remodeling. Pulmonary artery smooth muscle cells (PASMCs) from PAH patients are hyperproliferative and apoptosis-resistant and demonstrate decreased signaling in response to bone morphogenetic protei...

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Main Authors: Schwappacher, Raphaela, Kilic, Ana, Kojonazarov, Baktybek, Lang, Michaela, Diep, Thuan, Zhuang, Shunhui, Gawlowski, Thomas, Schermuly, Ralph T., Pfeifer, Alexander, Boss, Gerry R., Pilz, Renate B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675591/
https://ncbi.nlm.nih.gov/pubmed/23612967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.458729
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