Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling

Receptor interacting protein 3 (RIP3) is a protein kinase essential for TNF-induced necroptosis. Phosphorylation on Ser-227 in human RIP3 (hRIP3) is required for its interaction with human mixed lineage kinase domain-like (MLKL) in the necrosome, a signaling complex induced by TNF stimulation. RIP1...

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Autors principals: Chen, Wanze, Zhou, Zhenru, Li, Lisheng, Zhong, Chuan-Qi, Zheng, Xinru, Wu, Xiurong, Zhang, Yingying, Ma, Huan, Huang, Deli, Li, Wenjuan, Xia, Zongping, Han, Jiahuai
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675564/
https://ncbi.nlm.nih.gov/pubmed/23612963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.435545
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