Crystal structures of Escherichia coli exonuclease I in complex with single-stranded DNA provide insights into the mechanism of processive digestion

Escherichia coli Exonuclease I (ExoI) digests single-stranded DNA (ssDNA) in the 3′-5′ direction in a highly processive manner. The crystal structure of ExoI, determined previously in the absence of DNA, revealed a C-shaped molecule with three domains that form a central positively charged groove. T...

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Autores principales: Korada, Sai Krishna C., Johns, Trevor D., Smith, Christopher E., Jones, Nathan D., McCabe, Kimberly A., Bell, Charles E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675492/
https://ncbi.nlm.nih.gov/pubmed/23609540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt278
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