Details of ssDNA annealing revealed by an HSV-1 ICP8–ssDNA binary complex

Infected cell protein 8 (ICP8) from herpes simplex virus 1 was first identified as a single-strand (ss) DNA-binding protein. It is essential for, and abundant during, viral replication. Studies in vitro have shown that ICP8 stimulates model replication reactions, catalyzes annealing of complementary...

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Bibliographic Details
Main Authors: Tolun, Gökhan, Makhov, Alexander M., Ludtke, Steven J., Griffith, Jack D.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675482/
https://ncbi.nlm.nih.gov/pubmed/23605044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt266
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