MiR-7 Triggers Cell Cycle Arrest at the G1/S Transition by Targeting Multiple Genes Including Skp2 and Psme3

MiR-7 acts as a tumour suppressor in many cancers and abrogates proliferation of CHO cells in culture. In this study we demonstrate that miR-7 targets key regulators of the G1 to S phase transition, including Skp2 and Psme3, to promote increased levels of p27(KIP) and temporary growth arrest of CHO...

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Detalhes bibliográficos
Principais autores: Sanchez, Noelia, Gallagher, Mark, Lao, Nga, Gallagher, Clair, Clarke, Colin, Doolan, Padraig, Aherne, Sinead, Blanco, Alfonso, Meleady, Paula, Clynes, Martin, Barron, Niall
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675065/
https://ncbi.nlm.nih.gov/pubmed/23762407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065671
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