Resistance to Oncolytic Myxoma Virus Therapy in Nf1(−/−)/Trp53(−/−) Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon

Despite promising preclinical studies, oncolytic viral therapy for malignant gliomas has resulted in variable, but underwhelming results in clinical evaluations. Of concern are the low levels of tumour infection and viral replication within the tumour. This discrepancy between the laboratory and the...

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Detalhes bibliográficos
Main Authors: Zemp, Franz J., McKenzie, Brienne A., Lun, Xueqing, Maxwell, Lori, Reilly, Karlyne M., McFadden, Grant, Yong, V. Wee, Forsyth, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675064/
https://ncbi.nlm.nih.gov/pubmed/23762429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065801
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