M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma

BACKGROUND: Myxoma virus (MYXV) is a promising oncolytic agent and is highly effective against immortalized glioma cells but less effective against brain tumor initiating cells (BTICs), which are believed to mediate glioma development/recurrence. MYXV encodes various proteins to attenuate host cell...

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Vydáno v:Neuro Oncol
Hlavní autoři: Pisklakova, Alexandra, McKenzie, Brienne, Zemp, Franz, Lun, Xueqing, Kenchappa, Rajappa S., Etame, Arnold B., Rahman, Masmudur M., Reilly, Karlyne, Pilon-Thomas, Shari, McFadden, Grant, Kurz, Ebba, Forsyth, Peter A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933479/
https://ncbi.nlm.nih.gov/pubmed/26962017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now006
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