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Combinatorial Clustering of Residue Position Subsets Predicts Inhibitor Affinity across the Human Kinome
The protein kinases are a large family of enzymes that play fundamental roles in propagating signals within the cell. Because of the high degree of binding site similarity shared among protein kinases, designing drug compounds with high specificity among the kinases has proven difficult. However, co...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3675009/ https://ncbi.nlm.nih.gov/pubmed/23754939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003087 |
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