ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response

BACKGROUND: The Grin1 (glutamate receptor, ionotropic, NMDA1) gene expresses a subunit of N-methyl-D-aspartate (NMDA) receptors that is considered to play an important role in excitatory neurotransmission, synaptic plasticity, and brain development. Grin1 is a candidate susceptibility gene for neuro...

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Detalhes bibliográficos
Main Authors: Umemori, Juzoh, Takao, Keizo, Koshimizu, Hisatsugu, Hattori, Satoko, Furuse, Tamio, Wakana, Shigeharu, Miyakawa, Tsuyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674941/
https://ncbi.nlm.nih.gov/pubmed/23688147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-6-203
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