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Comparison of Nerve Growth Factor Receptor Binding Models Using Heterodimeric Muteins
Nerve growth factor (NGF) is a homodimer that binds to two distinct receptor types, TrkA and p75, to support survival and differentiation of neurons. The high-affinity binding on the cell surface is believed to involve a heteroreceptor complex, but its exact nature is unclear. We developed a heterod...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674885/ https://ncbi.nlm.nih.gov/pubmed/22903500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.23116 |
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