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PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca(2+) sensitivity
During physical exercise and stress, the sympathetic system stimulates cardiac contractility via β-adrenergic receptor activation, resulting in protein kinase A (PKA)-mediated phosphorylation of the cardiac ryanodine receptor, RyR2, at Ser2808. Hyperphosphorylation of RyR2-S2808 has been proposed as...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674825/ https://ncbi.nlm.nih.gov/pubmed/22487381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.03.015 |
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