Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in adults. Aberrant activation of Hedgehog (Hh) and nuclear factor (NF)-κB pathways is ubiquitously observed and known to mediate tumor growth, survival, and chemoresistance in DLBCL. Here, we find that activation of Hh sig...

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Detalhes bibliográficos
Main Authors: Qu, Changju, Liu, Yadong, Kunkalla, Kranthi, Singh, Rajesh R., Blonska, Marzenna, Lin, Xin, Agarwal, Nitin Kumar, Vega, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674670/
https://ncbi.nlm.nih.gov/pubmed/23632891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-470153
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