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Readthrough Strategies for Suppression of Nonsense Mutations in Duchenne/Becker Muscular Dystrophy: Aminoglycosides and Ataluren (PTC124)
Nucleotide changes within an exon may alter the trinucleotide normally encoding a particular amino acid, such that a new “stop” signal is transcribed into the mRNA open reading frame. This causes the ribosome to prematurely terminate its reading of the mRNA, leading to nonsense-mediated decay of the...
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| Formato: | Artigo |
| Idioma: | Inglês |
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2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674569/ https://ncbi.nlm.nih.gov/pubmed/20519671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0883073810371129 |
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