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Shank2 contributes to the apical retention and intracellular redistribution of NaPiIIa in OK cells

In renal proximal tubule (PT) cells, sodium-phosphate cotransporter IIa (NaPiIIa) is normally concentrated within the apical membrane where it reabsorbs ∼70% of luminal phosphate (Pi). NaPiIIa activity is acutely regulated by moderating its abundance within the apical membrane. Under low-Pi conditio...

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Autors principals: Dobrinskikh, Evgenia, Lanzano, Luca, Rachelson, Joanna, Cranston, DeeAnn, Moldovan, Radu, Lei, Tim, Gratton, Enrico, Doctor, R. Brian
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674434/
https://ncbi.nlm.nih.gov/pubmed/23325414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00189.2012
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