A Nonlinear Mixed Effects Pharmacokinetic Model for Dapagliflozin and Dapagliflozin 3-O-glucuronide in Renal or Hepatic Impairment

Dapagliflozin is a sodium–glucose co-transporter 2 inhibitor in development for the treatment of type 2 diabetes mellitus. A semi-mechanistic population pharmacokinetic (PK) model was developed for dapagliflozin and its inactive metabolite dapagliflozin 3-O-glucuronide (D3OG) with emphasis on renal...

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Main Authors: van der Walt, J-S, Hong, Y, Zhang, L, Pfister, M, Boulton, D W, Karlsson, M O
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674329/
https://ncbi.nlm.nih.gov/pubmed/23887724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.20
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