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Connexin 43 impacts on mitochondrial potassium uptake

In cardiomyocytes, connexin 43 (Cx43) forms gap junctions and unopposed hemichannels at the plasma membrane, but the protein is also present at the inner membrane of subsarcolemmal mitochondria (SSM). Both inhibition and genetic ablation of Cx43 reduce ADP-stimulated complex 1 respiration. Since mit...

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Bibliografiske detaljer
Main Authors: Boengler, Kerstin, Ungefug, Elvira, Heusch, Gerd, Leybaert, Luc, Schulz, Rainer
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674322/
https://ncbi.nlm.nih.gov/pubmed/23760924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2013.00073
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