Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

DNA topoisomerase II inhibitors are a major class of cancer chemotherapeutics, which are thought to eliminate cancer cells by inducing DNA double-strand breaks. Here we identify a novel activity for the anthracycline class of DNA topoisomerase II inhibitors: histone eviction from open chromosomal ar...

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Main Authors: Pang, Baoxu, Qiao, Xiaohang, Janssen, Lennert, Velds, Arno, Groothuis, Tom, Kerkhoven, Ron, Nieuwland, Marja, Ovaa, Huib, Rottenberg, Sven, van Tellingen, Olaf, Janssen, Jeroen, Huijgens, Peter, Zwart, Wilbert, Neefjes, Jacques
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674280/
https://ncbi.nlm.nih.gov/pubmed/23715267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2921
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