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Dual Targeting of the Type 1 Insulin-like Growth Factor Receptor and its Ligands as an Effective Anti-angiogenic Strategy

BACKGROUND: In pediatric tumor xenograft models, tumor-derived IGF-2 results in intrinsic resistance to IGF-1R-targeted antibodies, maintaining continued tumor angiogenesis. We evaluated the anti-angiogenic activity of a ligand-binding antibody (MEDI-573) alone or in combination with IGF-1 receptor...

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Detalhes bibliográficos
Main Authors: Bid, Hemant K., London, Cheryl A., Gao, Jin, Zhong, Haihong, Hollingsworth, Robert E., Fernandez, Soledad, Mo, Xiaokui, Houghton, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674221/
https://ncbi.nlm.nih.gov/pubmed/23549869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2008
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