DACHSHUND BINDS P53 TO BLOCK THE GROWTH OF LUNG ADENOCARCINOMA CELLS

Hyperactive EGFR and mutant p53 are common genetic abnormalities driving the progression of non-small cell lung cancer (NSCLC), the leading cause of cancer deaths in the world. The Drosophila gene Dachshund (Dac) was originally cloned as an inhibitor of hyperactive EGFR alleles. Given the importance...

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Bibliografiska uppgifter
Huvudupphovsmän: Chen, Ke, Wu, Kongming, Cai, Shaoxin, Zhang, Wei, Zhou, Jie, Wang, Jing, Ertel, Adam, Li, Zhiping, Rui, Hallgeir, Quong, Andrew, Lisanti, Michael P., Tozeren, Aydin, Tanes, Ceylan, Addya, Sankar, Wang, L. Andrew Shirley Chenguang, McMahon, Steven, Pestell, Richard G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674204/
https://ncbi.nlm.nih.gov/pubmed/23492369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3191
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