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Clonal evolution, genomic drivers and effects of therapy in chronic lymphocytic leukemia

PURPOSE: The identification of gene mutations and structural genomic aberrations that are critically involved in CLL pathogenesis is still evolving. One may postulate that genomic driver lesions with effects on CLL cell proliferation, apoptosis thresholds or chemotherapy resistance should increase i...

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Detalhes bibliográficos
Main Authors: Ouillette, Peter, Saiya-Cork, Kamlai, Seymour, Erlene, Li, Cheng, Shedden, Kerby, Malek, Sami N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674194/
https://ncbi.nlm.nih.gov/pubmed/23620403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0138
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