Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation

The selective pressures leading to cancers with mutations in both KRAS and PIK3CA are unclear. Here we demonstrate that somatic cell knock in of both KRAS G12V and oncogenic PIK3CA mutations in human breast epithelial cells results in cooperative activation of the PI3 Kinase and MAP Kinase pathways...

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Hlavní autoři: Wang, Grace M., Wong, Hong-Yuen, Konishi, Hiroyuki, Blair, Brian G., Abukhdeir, Abde, Gustin, John P., Rosen, D. Marc, Denmeade, Samuel, Rasheed, Zeshaan, Matsui, William, Garay, Joseph P., Mohseni, Morassa, Higgins, Michaela J., Cidado, Justin, Jelovac, Danijela, Croessmann, Sarah, Cochran, Rory, Karnan, Sivasundaram, Konishi, Yuko, Ota, Akinobu, Hosokawa, Yoshitaka, Argani, Pedram, Lauring, Josh, Park, Ben Ho
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674106/
https://ncbi.nlm.nih.gov/pubmed/23580570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1578
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