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Role of the Iodothyronine Deiodinases in the Physiology and Pathophysiology of Thyroid Hormone Action

Thyroxine (T4) is a prohormone and must be activated to 3,5,3′-triiodothyronine (T3) by either type 1 (D1) or type 2 (D2) selenodeiodinase. A third deiodinase (D3) inactivates T3 or T4 by removal of an inner ring iodine. These reactions require both a deiodinase enzyme and a cofactor, probably a thi...

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Bibliografski detalji
Glavni autori: Larsen, P. Reed, Zavacki, Ann Marie
Format: Artigo
Jezik:Inglês
Izdano: S. Karger AG 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673746/
https://ncbi.nlm.nih.gov/pubmed/23750337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000343922
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