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Role of the Iodothyronine Deiodinases in the Physiology and Pathophysiology of Thyroid Hormone Action
Thyroxine (T4) is a prohormone and must be activated to 3,5,3′-triiodothyronine (T3) by either type 1 (D1) or type 2 (D2) selenodeiodinase. A third deiodinase (D3) inactivates T3 or T4 by removal of an inner ring iodine. These reactions require both a deiodinase enzyme and a cofactor, probably a thi...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
S. Karger AG
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3673746/ https://ncbi.nlm.nih.gov/pubmed/23750337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000343922 |
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