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Inhibition of Grb2-mediated activation of MAPK signal transduction suppresses NOR(1)/CB1954-induced cytotoxicity in the HepG2 cell line

The nitroreductase oxidored-nitro domain containing protein 1 (NOR(1)) gene may be involved in the chemical carcinogenesis of hepatic cancer and nasopharyngeal carcinoma (NPC). We have previously demonstrated that NOR(1) overexpression is capable of converting the monofunctional alkylating agent 5-(...

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Bibliografiske detaljer
Main Authors: GUI, RONG, LI, DENGQING, QI, GUANNAN, SUHAD, ALI, NIE, XINMIN
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673652/
https://ncbi.nlm.nih.gov/pubmed/23741254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2012.774
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